Please use this identifier to cite or link to this item:
|Title:||Effect of rutin on warfarin anticoagulation and pharmacokinetics of warfarin enantiomers in rats|
|Authors:||Chan, E. |
Stereoselective drug interactions
|Citation:||Chan, E., Hegde, A., Chen, X. (2009-04). Effect of rutin on warfarin anticoagulation and pharmacokinetics of warfarin enantiomers in rats. Journal of Pharmacy and Pharmacology 61 (4) : 451-458. ScholarBank@NUS Repository. https://doi.org/10.1211/jpp/61.04.0006|
|Abstract:||Objectives: The effects of the flavonoid rutin on the anticoagulant activity of oral warfarin and the protein binding and pharmacokinetics of its enantiomers were investigated in rats. Methods: A single dose of racemic warfarin, 1.5 mg/kg, was administered orally to rats either alone or on day 5 of an 8-day oral regimen of rutin, 1 g/kg daily. Results: Rutin reduced the anticoagulant effect of racemic warfarin, evident as a 31% reduction in the area under the prothrombin complex activty - time curve (P < 0.05). Key findings: Rutin had no apparent effect on pre-treatment baseline blood coagulation. It enhanced the in-vitro serum protein binding of S- and R-warfarin (reflected by 40% and 26% reductions in unbound fraction, respectively), and thus restricted distribution by 33 and 21%, respectively. Treatment with rutin significantly decreased the elimination half-life of S-warfarin by 37% as a result of the 69% increase in unbound clearance of the S-enantiomer. This effect was attributed to a significant 77% increase in the unbound formation clearance of the overall oxidative and reductive metabolites, and an increase in the unbound renal clearance of the more potent S-enantiomer of warfarin. Conclusions: Concurrent rutin administration is likely to reduce the anticoagulant effect of racemic warfarin, reflecting a significant decrease in the elimination half-life of the more potent S-enantiomer. © 2009 The Authors.|
|Source Title:||Journal of Pharmacy and Pharmacology|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on May 22, 2018
WEB OF SCIENCETM
checked on May 22, 2018
checked on May 25, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.