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|Title:||Determination of adefovir in human plasma by liquid chromatography/tandem mass spectrometry: Application to a pharmacokinetic study|
|Source:||Bi, H.-C., Zhong, G.-P., Zhou, S., Chen, X., Huang, M. (2005). Determination of adefovir in human plasma by liquid chromatography/tandem mass spectrometry: Application to a pharmacokinetic study. Rapid Communications in Mass Spectrometry 19 (20) : 2911-2917. ScholarBank@NUS Repository. https://doi.org/10.1002/rcm.2141|
|Abstract:||A liquid chromatography/tandem mass spectrometry (LC/MS/MS) method was developed and validated to determine the concentrations of adefovir [9-(2-phosphonylmethoxyethyl)adenine, PMEA] in human plasma. After one-step protein precipitation of plasma samples by methanol, adefovir was analyzed by LC/MS/MS using positive electrospray ionization. Chromatography was performed on a C18 column. The extraction recoveries of adefovir were found to be 85.1-89.3%. Adefovir was stable under routine laboratory conditions. A minimal matrix effect resulting in a slight ionization enhancement of adefovir (|
|Source Title:||Rapid Communications in Mass Spectrometry|
|Appears in Collections:||Staff Publications|
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