Determination of adefovir in human plasma by liquid chromatography/tandem mass spectrometry: Application to a pharmacokinetic study

Please use this identifier to cite or link to this item: https://doi.org/10.1002/rcm.2141

Title:	Determination of adefovir in human plasma by liquid chromatography/tandem mass spectrometry: Application to a pharmacokinetic study
Authors:	Bi, H.-C. Zhong, G.-P. Zhou, S. Chen, X. Huang, M.
Issue Date:	2005
Citation:	Bi, H.-C., Zhong, G.-P., Zhou, S., Chen, X., Huang, M. (2005). Determination of adefovir in human plasma by liquid chromatography/tandem mass spectrometry: Application to a pharmacokinetic study. Rapid Communications in Mass Spectrometry 19 (20) : 2911-2917. ScholarBank@NUS Repository. https://doi.org/10.1002/rcm.2141
Abstract:	A liquid chromatography/tandem mass spectrometry (LC/MS/MS) method was developed and validated to determine the concentrations of adefovir [9-(2-phosphonylmethoxyethyl)adenine, PMEA] in human plasma. After one-step protein precipitation of plasma samples by methanol, adefovir was analyzed by LC/MS/MS using positive electrospray ionization. Chromatography was performed on a C18 column. The extraction recoveries of adefovir were found to be 85.1-89.3%. Adefovir was stable under routine laboratory conditions. A minimal matrix effect resulting in a slight ionization enhancement of adefovir (
Source Title:	Rapid Communications in Mass Spectrometry
URI:	http://scholarbank.nus.edu.sg/handle/10635/105800
ISSN:	09514198
DOI:	10.1002/rcm.2141
Appears in Collections:	Staff Publications

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