Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jinorgbio.2007.01.010
Title: Cytotoxicity, qualitative structure-activity relationship (QSAR), and anti-tumor activity of bismuth dithiocarbamate complexes
Authors: Li, H.
Lai, C.S. 
Wu, J.
Ho, P.C. 
de Vos, D.
Tiekink, E.R.T.
Keywords: Anti-tumor
Bismuth complexes
Cytotoxicity
Dithiocarbamate complexes
Issue Date: May-2007
Source: Li, H., Lai, C.S., Wu, J., Ho, P.C., de Vos, D., Tiekink, E.R.T. (2007-05). Cytotoxicity, qualitative structure-activity relationship (QSAR), and anti-tumor activity of bismuth dithiocarbamate complexes. Journal of Inorganic Biochemistry 101 (5) : 809-816. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jinorgbio.2007.01.010
Abstract: Bismuth dithiocarbamate complexes of general formula Bi(S2CNR2)3 demonstrate potent in vitro cytotoxicity against a panel of seven human cancer cell lines; a structure-activity relationship has been established. Potency exhibited by the R = Et (2) derivative, for example, is unrivalled by standard cancer drugs with the exception of paclitaxel. In vivo studies indicate a significant anti-tumor effect exerted by (2) against both OVCAR-3, an ovarian cancer cell line, and HT-29, a colon carcinoma cell line. © 2007 Elsevier Inc. All rights reserved.
Source Title: Journal of Inorganic Biochemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/105791
ISSN: 01620134
DOI: 10.1016/j.jinorgbio.2007.01.010
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