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|Title:||Cytotoxicity, qualitative structure-activity relationship (QSAR), and anti-tumor activity of bismuth dithiocarbamate complexes|
de Vos, D.
|Source:||Li, H., Lai, C.S., Wu, J., Ho, P.C., de Vos, D., Tiekink, E.R.T. (2007-05). Cytotoxicity, qualitative structure-activity relationship (QSAR), and anti-tumor activity of bismuth dithiocarbamate complexes. Journal of Inorganic Biochemistry 101 (5) : 809-816. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jinorgbio.2007.01.010|
|Abstract:||Bismuth dithiocarbamate complexes of general formula Bi(S2CNR2)3 demonstrate potent in vitro cytotoxicity against a panel of seven human cancer cell lines; a structure-activity relationship has been established. Potency exhibited by the R = Et (2) derivative, for example, is unrivalled by standard cancer drugs with the exception of paclitaxel. In vivo studies indicate a significant anti-tumor effect exerted by (2) against both OVCAR-3, an ovarian cancer cell line, and HT-29, a colon carcinoma cell line. © 2007 Elsevier Inc. All rights reserved.|
|Source Title:||Journal of Inorganic Biochemistry|
|Appears in Collections:||Staff Publications|
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