Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/105773
Title: Conformational and structural features determining in vitro antimalarial activity in some indolo[3,2-c]quinolines, anilinoquinolines and tetrahydroindolo[3,2-d]benzazepines
Authors: Koh, H. 
Go, M. 
Ngiam, T. 
Mak, J.
Keywords: anilinoquinoline
antimalarial activity
indolo[3,2-c]quinoline
SAR
tetrahydroindolo[3,2-d]benzazepine
Issue Date: 1994
Citation: Koh, H.,Go, M.,Ngiam, T.,Mak, J. (1994). Conformational and structural features determining in vitro antimalarial activity in some indolo[3,2-c]quinolines, anilinoquinolines and tetrahydroindolo[3,2-d]benzazepines. European Journal of Medicinal Chemistry 29 (2) : 107-113. ScholarBank@NUS Repository.
Abstract: A series of indolo[3,2-c]quinolines, anilinoquinolines and tetrahydroindolo[3,2-d]benzazepines, which differ in the conformational planarity of the key nuclei and the distance (N...N+) between the ring and side-chain nitrogen atoms, have been synthesized and evaluated in vitro against a number of isolates of Plasmodium falciparum. The results show that differences in conformational planarity of the indolo[3,2-c]quinoline (rigid), anilinoquinoline (flexible) and tetrahydroindolo[3,2-d]benzazepine (semi-rigid) nuclei have little effect on activity. However, the N...N+ distance is an important determinant of activity and analogues with a distance comparable to the N...N+ distance of amodiaquine and chloroquine demonstrated antimalarial activity. © 1994.
Source Title: European Journal of Medicinal Chemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/105773
ISSN: 02235234
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

79
checked on Oct 19, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.