A new synthesis of 2,8-disubstituted pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines

Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.tetlet.2009.07.113

Title:	A new synthesis of 2,8-disubstituted pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines
Authors:	Dolzhenko, A.V. Pastorin, G. Dolzhenko, A.V. Chui, W.K.
Issue Date:	7-Oct-2009
Citation:	Dolzhenko, A.V., Pastorin, G., Dolzhenko, A.V., Chui, W.K. (2009-10-07). A new synthesis of 2,8-disubstituted pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines. Tetrahedron Letters 50 (40) : 5617-5621. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tetlet.2009.07.113
Abstract:	A practical synthesis of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines, which are key intermediates in the preparation of adenosine receptor antagonists, is developed. The method allows introduction of a variety of aryl substituents at position 2 of the pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine system via cyclocondensation of 5-amino-4-iminopyrazolo[3,4-d]pyrimidine with benzaldehydes accompanied with oxidation by iodobenzene diacetate. Some unexpected reactions are observed and the structures of the products are confirmed using NMR spectroscopy and X-ray crystallography. © 2009 Elsevier Ltd. All rights reserved.
Source Title:	Tetrahedron Letters
URI:	http://scholarbank.nus.edu.sg/handle/10635/105575
ISSN:	00404039
DOI:	10.1016/j.tetlet.2009.07.113
Appears in Collections:	Staff Publications

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