A convenient method for the synthesis of 7-amino-substituted 1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amines

Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.tetlet.2008.10.003

Title:	A convenient method for the synthesis of 7-amino-substituted 1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amines
Authors:	Dolzhenko, A.V. Pastorin, G. Dolzhenko, A.V. Chui, W.K.
Issue Date:	8-Dec-2008
Citation:	Dolzhenko, A.V., Pastorin, G., Dolzhenko, A.V., Chui, W.K. (2008-12-08). A convenient method for the synthesis of 7-amino-substituted 1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amines. Tetrahedron Letters 49 (50) : 7180-7183. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tetlet.2008.10.003
Abstract:	A new practical synthesis of 7-amino-substituted 1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amines is developed. The triazine ring closure of 5-guanidino-3-phenyl-1,2,4-triazole with trichloroacetonitrile proceeds chemo- and regioselectively depending on the nature of the solvent. Conducting the reaction in toluene provided 7-trichloromethyl-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amine as the product, which can be further aminated efficiently with replacement of the trichloromethyl group. © 2008 Elsevier Ltd. All rights reserved.
Source Title:	Tetrahedron Letters
URI:	http://scholarbank.nus.edu.sg/handle/10635/105557
ISSN:	00404039
DOI:	10.1016/j.tetlet.2008.10.003
Appears in Collections:	Staff Publications

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