Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/105555
Title: A comparison of glutathione S-transferase mutant frequencies in healthy Han and Uygur Chinese
Authors: Shi-Long, Z.
Zhou, S. 
Huang, M.
Keywords: Genotype
Glutathione S-transferase
Han Chinese
Uygur Chinese
Issue Date: Jul-2005
Source: Shi-Long, Z.,Zhou, S.,Huang, M. (2005-07). A comparison of glutathione S-transferase mutant frequencies in healthy Han and Uygur Chinese. European Journal of Drug Metabolism and Pharmacokinetics 30 (3) : 181-185. ScholarBank@NUS Repository.
Abstract: Objective: This study was to compare the frequencies of genetic polymorphisms of GSTM1, GSTT1, and GSTP1 in Uygur Chinese with those in Han Chinese. Methods: GSTM1 and GSTT1 polymorphisms were analyzed by a PCR-Multiplex procedure, whereas GSTP1 polymorphism was analyzed by PCR-RFLP. Results: The frequency of GSTM1 null genotype in Han Chinese (56.1%) was similar to that in Uygur Chinese (53.2%) (P = 0.592), whilst the frequency of GSTT1 null genotype in Han Chinese (50.0%) was significantly (P < 0.05) higher than that of Uygur Chinese (26.6%). GSTP1 had a genotype distribution of 60.7% I/I, 35.2% I/V and 4.1% V/V in Han Chinese, and 51.3% I/I, 40.2% I/V and 8.4% V/V in Uygur Chinese. Conclusion: There is marked ethnic difference in the mutant frequencies of GSTT1 and GSTP1, but not GSTM1, between Uygur and Han Chinese.
Source Title: European Journal of Drug Metabolism and Pharmacokinetics
URI: http://scholarbank.nus.edu.sg/handle/10635/105555
ISSN: 03787966
Appears in Collections:Staff Publications

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