Please use this identifier to cite or link to this item: https://doi.org/10.1373/clinchem.2011.172346
Title: Estimating glomerular filtration rates by use of both cystatin C and standardized serum creatinine avoids ethnicity coefficients in asian patients with chronic kidney disease
Authors: Teo, B.W.
Xu, H.
Wang, D.
Li, J. 
Sinha, A.K.
Shuter, B.
Sethi, S.
Lee, E.J.C.
Issue Date: Feb-2012
Citation: Teo, B.W., Xu, H., Wang, D., Li, J., Sinha, A.K., Shuter, B., Sethi, S., Lee, E.J.C. (2012-02). Estimating glomerular filtration rates by use of both cystatin C and standardized serum creatinine avoids ethnicity coefficients in asian patients with chronic kidney disease. Clinical Chemistry 58 (2) : 450-457. ScholarBank@NUS Repository. https://doi.org/10.1373/clinchem.2011.172346
Abstract: BACKGROUND: The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation is most accurate for estimating glomerular filtration rate (GFR) but requires an adjustment for African-American patients. Estimation equations are also improved with the use of serum cystatin C combined with standardized creatinine. Combination equations have been derived by the CKD-EPI and Chinese investigators. We investigated whether these cystatin C-based equations improve estimation adequately, so that adjustments for ethnicity are not required in a multiethnic Asian population with chronic kidney disease (CKD). METHODS: This was a cross-sectional study of 232 stable CKD patients who underwent GFR measurements using 3-sample plasma clearances of 99mTc-DTPA, and for whom serum cystatin C and creatinine were quantified. RESULTS: For all patients, the median biases with cystatin C equations were generally greater than with the CKD-EPI equation, and precision and root mean square error (RMSE) were not significantly better. However, the combination serum creatinine and cystatin C equation improved the precision, RMSE, and percentage of estimated GFR to within 15% and 30% of the measured GFR (57.3% vs 50.0%, 88.4% vs 82.8%, respectively). The derived ethnicity coefficients for the combination equation were all >1 (1.009 -1.082) but small, suggesting that coefficients are not required. The Chinese-specific equations were more biased and performed more poorly than the CKD-EPI equation. CONCLUSIONS: The use of a cystatin C and creatinine combination equation for estimating GFR in a multi-ethnic Asian population with CKD does not require ethnicity coefficients because the derived coefficients are very close to each other. © 2011 American Association for Clinical Chemistry.
Source Title: Clinical Chemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/105122
ISSN: 00099147
DOI: 10.1373/clinchem.2011.172346
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