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Title: Transcriptomic analysis of pluripotent stem cells: Insights into health and disease
Authors: Yeo, J.-C.
Ng, H.-H. 
Keywords: Embryonic stem cells
Gene expression
Induced pluripotent stem cells
Pluripotencyregenerative medicine
Transcriptional regulation
Issue Date: 27-Oct-2011
Citation: Yeo, J.-C., Ng, H.-H. (2011-10-27). Transcriptomic analysis of pluripotent stem cells: Insights into health and disease. Genome Medicine 3 (10) : -. ScholarBank@NUS Repository.
Abstract: Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) hold tremendous clinical potential because of their ability to self-renew, and to differentiate into all cell types of the body. This unique capacity of ESCs and iPSCs to form all cell lineages is termed pluripotency. While ESCs and iPSCs are pluripotent and remarkably similar in appearance, whether iPSCs truly resemble ESCs at the molecular level is still being debated. Further research is therefore needed to resolve this issue before iPSCs may be safely applied in humans for cell therapy or regenerative medicine. Nevertheless, the use of iPSCs as an in vitro human genetic disease model has been useful in studying the molecular pathology of complex genetic diseases, as well as facilitating genetic or drug screens. Here, we review recent progress in transcriptomic approaches in the study of ESCs and iPSCs, and discuss how deregulation of these pathways may be involved in the development of disease. Finally, we address the importance of these advances for developing new therapeutics, and the future challenges facing the clinical application of ESCs and iPSCs. © 2011 BioMed Central Ltd.
Source Title: Genome Medicine
ISSN: 1756994X
DOI: 10.1186/gm284
Appears in Collections:Staff Publications

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