Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.stem.2009.03.005
Title: Molecules that Promote or Enhance Reprogramming of Somatic Cells to Induced Pluripotent Stem Cells
Authors: Feng, B.
Ng, J.-H.
Heng, J.-C.D.
Ng, H.-H. 
Issue Date: 3-Apr-2009
Citation: Feng, B., Ng, J.-H., Heng, J.-C.D., Ng, H.-H. (2009-04-03). Molecules that Promote or Enhance Reprogramming of Somatic Cells to Induced Pluripotent Stem Cells. Cell Stem Cell 4 (4) : 301-312. ScholarBank@NUS Repository. https://doi.org/10.1016/j.stem.2009.03.005
Abstract: Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) can be achieved by viral-mediated transduction of defined transcription factors. Moving toward the eventual goal of clinical application, it is necessary to overcome limitations such as low reprogramming efficiency and genomic alterations due to viral integration. Here, we review recent progress made in the usage of genetic factors, chemical inhibitors, and signaling molecules that can either replace core reprogramming factors or enhance reprogramming efficiency. Current iPSC studies will provide a paradigm for the combinatorial use of genetic factors and chemicals for the broader applications to alter cellular states of potency. © 2009 Elsevier Inc. All rights reserved.
Source Title: Cell Stem Cell
URI: http://scholarbank.nus.edu.sg/handle/10635/102494
ISSN: 19345909
DOI: 10.1016/j.stem.2009.03.005
Appears in Collections:Staff Publications

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