Please use this identifier to cite or link to this item:
|Title:||Molecules that Promote or Enhance Reprogramming of Somatic Cells to Induced Pluripotent Stem Cells|
|Citation:||Feng, B., Ng, J.-H., Heng, J.-C.D., Ng, H.-H. (2009-04-03). Molecules that Promote or Enhance Reprogramming of Somatic Cells to Induced Pluripotent Stem Cells. Cell Stem Cell 4 (4) : 301-312. ScholarBank@NUS Repository. https://doi.org/10.1016/j.stem.2009.03.005|
|Abstract:||Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) can be achieved by viral-mediated transduction of defined transcription factors. Moving toward the eventual goal of clinical application, it is necessary to overcome limitations such as low reprogramming efficiency and genomic alterations due to viral integration. Here, we review recent progress made in the usage of genetic factors, chemical inhibitors, and signaling molecules that can either replace core reprogramming factors or enhance reprogramming efficiency. Current iPSC studies will provide a paradigm for the combinatorial use of genetic factors and chemicals for the broader applications to alter cellular states of potency. © 2009 Elsevier Inc. All rights reserved.|
|Source Title:||Cell Stem Cell|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jun 16, 2018
WEB OF SCIENCETM
checked on May 16, 2018
checked on Mar 11, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.