Please use this identifier to cite or link to this item: https://doi.org/10.3390/cancers4041252
Title: Emerging roles of ADAMTSS in angiogenesis and cancer
Authors: Kumar, S.
Rao, N.
Ge, R. 
Keywords: ADAMTS
Angiogenesis
Cancer
Metalloproteinase
Metastasis
Proteoglycanase
Tumorigenesis
Issue Date: Dec-2012
Citation: Kumar, S.,Rao, N.,Ge, R. (2012-12). Emerging roles of ADAMTSS in angiogenesis and cancer. Cancers 4 (4) : 1252-1299. ScholarBank@NUS Repository. https://doi.org/10.3390/cancers4041252
Abstract: A Disintegrin-like And Metalloproteinase with ThromboSpondin motifs- ADAMTSs-are a multi-domain, secreted, extracellular zinc metalloproteinase family with 19 members in humans. These extracellular metalloproteinases are known to cleave a wide range of substrates in the extracellular matrix. They have been implicated in various physiological processes, such as extracellular matrix turnover, melanoblast development, interdigital web regression, blood coagulation, ovulation, etc. ADAMTSs are also critical in pathological processes such as arthritis, atherosclerosis, cancer, angiogenesis, wound healing, etc. In the past few years, there has been an explosion of reports concerning the role of ADAMTS family members in angiogenesis and cancer. To date, 10 out of the 19 members have been demonstrated to be involved in regulating angiogenesis and/or cancer. The mechanism involved in their regulation of angiogenesis or cancer differs among different members. Both angiogenesis-dependent and -independent regulation of cancer have been reported. This review summarizes our current understanding on the roles of ADAMTS in angiogenesis and cancer and highlights their implications in cancer therapeutic development. © 2012 by the authors; licensee MDPI, Basel, Switzerland.
Source Title: Cancers
URI: http://scholarbank.nus.edu.sg/handle/10635/102444
ISSN: 20726694
DOI: 10.3390/cancers4041252
Appears in Collections:Staff Publications

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