Please use this identifier to cite or link to this item:
|Title:||Zfp206, Oct4, and Sox2 are integrated components of a transcriptional regulatory network in embryonic stem cells|
|Authors:||Yu, H.-B. |
|Source:||Yu, H.-B., Kunarso, G., Hong, F.H., Stanton, L.W. (2009-11-06). Zfp206, Oct4, and Sox2 are integrated components of a transcriptional regulatory network in embryonic stem cells. Journal of Biological Chemistry 284 (45) : 31327-31335. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.M109.016162|
|Abstract:||Zfp206 (recently renamed Zsran10) encodes a zinc finger transcription factor specifically expressed in human and mouse embryonic stem cells (ESC). It has been shown that Zfp206 is required to maintain ESC in an undifferentiated, pluripotent state. Presented here are data showing that Zfp206 works together with two other transcription factors, Oct4 and Sox2, which are also essential regulators of ESC pluripotency. We show that Zfp206 binds to the Oct4 promoter and directly regulates Oct4 expression. Genome-wide mapping of Zfp206-binding sites in ESC identifies more than 3000 target genes, many of which encode transcription factors that are also targeted for regulation by Oct4 and Sox2. In addition, we show that Zfp206 physically interacts with both Oct4 and Sox2. These data demonstrate that Zfp206 is a key component of the core transcriptional regulatory network and together with Oct4 and Sox2 regulates differentiation of ESC. © 2009 by The American Society for Biochemistry and Molecular Biology, Inc.|
|Source Title:||Journal of Biological Chemistry|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Mar 8, 2018
WEB OF SCIENCETM
checked on Feb 7, 2018
checked on Mar 12, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.