Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0014-5793(98)00327-5
Title: The skin-type antifreeze protein gene intron of the winter flounder is a ubiquitous enhancer lacking a functional C/EBPα binding motif
Authors: Miao, M.
Chan, S.-L.
Hew, C.L.
Gong, Z. 
Keywords: Antifreeze protein
CCAAT/enhancer binding protein
Liver-type
Skin-type
Winter flounder
Issue Date: 10-Apr-1998
Citation: Miao, M., Chan, S.-L., Hew, C.L., Gong, Z. (1998-04-10). The skin-type antifreeze protein gene intron of the winter flounder is a ubiquitous enhancer lacking a functional C/EBPα binding motif. FEBS Letters 426 (1) : 121-125. ScholarBank@NUS Repository. https://doi.org/10.1016/S0014-5793(98)00327-5
Abstract: The winter flounder antifreeze protein (AFP) intron contains a liver- specific enhancer (Element B) which was shown earlier to bind CCAAT/enhancer binding protein (C/EBP)α. In contrast, as demonstrated in the present studies, the intron of the skin-type AFP gene acted as a ubiquitous enhancer and contained a TA insertion at similar region to Element B (Element S) which destroyed its interaction with C/EBPα. Furthermore, a TA insertion of Element B by site-directed mutagenesis decreased its liver enhancer activity. The presence or absence of C/EBPα binding motifs in Element B and Element S, respectively, may provide a mechanism for their differential expression.
Source Title: FEBS Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/102008
ISSN: 00145793
DOI: 10.1016/S0014-5793(98)00327-5
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