Please use this identifier to cite or link to this item:
|Title:||The skin-type antifreeze protein gene intron of the winter flounder is a ubiquitous enhancer lacking a functional C/EBPα binding motif|
CCAAT/enhancer binding protein
|Citation:||Miao, M., Chan, S.-L., Hew, C.L., Gong, Z. (1998-04-10). The skin-type antifreeze protein gene intron of the winter flounder is a ubiquitous enhancer lacking a functional C/EBPα binding motif. FEBS Letters 426 (1) : 121-125. ScholarBank@NUS Repository. https://doi.org/10.1016/S0014-5793(98)00327-5|
|Abstract:||The winter flounder antifreeze protein (AFP) intron contains a liver- specific enhancer (Element B) which was shown earlier to bind CCAAT/enhancer binding protein (C/EBP)α. In contrast, as demonstrated in the present studies, the intron of the skin-type AFP gene acted as a ubiquitous enhancer and contained a TA insertion at similar region to Element B (Element S) which destroyed its interaction with C/EBPα. Furthermore, a TA insertion of Element B by site-directed mutagenesis decreased its liver enhancer activity. The presence or absence of C/EBPα binding motifs in Element B and Element S, respectively, may provide a mechanism for their differential expression.|
|Source Title:||FEBS Letters|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jul 10, 2018
WEB OF SCIENCETM
checked on Jun 27, 2018
checked on Jun 14, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.