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|Title:||The skin-type antifreeze protein gene intron of the winter flounder is a ubiquitous enhancer lacking a functional C/EBPα binding motif|
CCAAT/enhancer binding protein
|Citation:||Miao, M., Chan, S.-L., Hew, C.L., Gong, Z. (1998-04-10). The skin-type antifreeze protein gene intron of the winter flounder is a ubiquitous enhancer lacking a functional C/EBPα binding motif. FEBS Letters 426 (1) : 121-125. ScholarBank@NUS Repository. https://doi.org/10.1016/S0014-5793(98)00327-5|
|Abstract:||The winter flounder antifreeze protein (AFP) intron contains a liver- specific enhancer (Element B) which was shown earlier to bind CCAAT/enhancer binding protein (C/EBP)α. In contrast, as demonstrated in the present studies, the intron of the skin-type AFP gene acted as a ubiquitous enhancer and contained a TA insertion at similar region to Element B (Element S) which destroyed its interaction with C/EBPα. Furthermore, a TA insertion of Element B by site-directed mutagenesis decreased its liver enhancer activity. The presence or absence of C/EBPα binding motifs in Element B and Element S, respectively, may provide a mechanism for their differential expression.|
|Source Title:||FEBS Letters|
|Appears in Collections:||Staff Publications|
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