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|Title:||The first but not the second thrombospondin type 1 repeat of ADAMTS5 functions as an angiogenesis inhibitor|
|Authors:||Sharghi-Namini, S. |
|Citation:||Sharghi-Namini, S., Fan, H., Sulochana, K.N., Potturi, P., Xiang, W., Chong, Y.-S., Wang, Z., Yang, H., Ge, R. (2008-06-27). The first but not the second thrombospondin type 1 repeat of ADAMTS5 functions as an angiogenesis inhibitor. Biochemical and Biophysical Research Communications 371 (2) : 215-219. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bbrc.2008.04.047|
|Abstract:||Angiogenesis is critical for tumour growth and metastasis where factors that regulate this process are potential targets for development of anti-cancer drugs. In this study, we show that the first TSR domain of the extracellular matrix protease ADAMTS5, unlike the second TSR, has anti-angiogenic activities where it inhibits endothelial cell tube formation on Matrigel, reduces cell proliferation and attachment, while promoting cell apoptosis and migration, all in a dose-dependent manner. Furthermore, it influences the architecture of endothelial cells by disrupting actin stress fibres and reducing focal adhesions, likely via suppressing RhoA activation. TSR1 of ADAMTS5 is therefore a novel anti-angiogenic peptide and could serve as a prototype for future development into anti-cancer drugs. © 2008 Elsevier Inc. All rights reserved.|
|Source Title:||Biochemical and Biophysical Research Communications|
|Appears in Collections:||Staff Publications|
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