Structural insights into the design of small molecule inhibitors that selectively antagonize Mcl-1

Please use this identifier to cite or link to this item: https://doi.org/10.1021/jm901469p

Title:	Structural insights into the design of small molecule inhibitors that selectively antagonize Mcl-1
Authors:	Bernardo, P.H. Sivaraman, T. Wan, K.-F. Xu, J. Krishnamoorthy, J. Sons, C.M. Tian, L. Chin, J.S.F. Lim, D.S.W. Mok, H.Y.K. Yu, V.C. Tong, J.C. Chai, C.L.L.
Issue Date:	11-Mar-2010
Citation:	Bernardo, P.H., Sivaraman, T., Wan, K.-F., Xu, J., Krishnamoorthy, J., Sons, C.M., Tian, L., Chin, J.S.F., Lim, D.S.W., Mok, H.Y.K., Yu, V.C., Tong, J.C., Chai, C.L.L. (2010-03-11). Structural insights into the design of small molecule inhibitors that selectively antagonize Mcl-1. Journal of Medicinal Chemistry 53 (5) : 2314-2318. ScholarBank@NUS Repository. https://doi.org/10.1021/jm901469p
Abstract:	The screening of a small focused library of rhodanine derivatives as inhibitors of Bcl-2 proteins led to the discovery of two structurally related compounds with different binding profiles against the Bcl-XL and the Mcl-1 proteins. Subsequent NMR studies with mutant proteins and in silico docking studies provide a possible rationale for the observed specificity. © 2010 American Chemical Society.
Source Title:	Journal of Medicinal Chemistry
URI:	http://scholarbank.nus.edu.sg/handle/10635/101765
ISSN:	00222623
DOI:	10.1021/jm901469p
Appears in Collections:	Staff Publications

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