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https://doi.org/10.1016/j.toxicon.2006.05.013
| Title: | Snake venom glutaminyl cyclase | Authors: | Pawlak, J. Manjunatha Kini, R. |
Keywords: | Glutaminyl cyclase Pyroglutamic acid Snake venom Three-finger toxins |
Issue Date: | 1-Sep-2006 | Citation: | Pawlak, J., Manjunatha Kini, R. (2006-09-01). Snake venom glutaminyl cyclase. Toxicon 48 (3) : 278-286. ScholarBank@NUS Repository. https://doi.org/10.1016/j.toxicon.2006.05.013 | Abstract: | Glutaminyl cyclase (QC) catalyzes N-terminal glutamine cyclization of many endocrine peptides and is typically abundant in brain tissue. As three-finger toxins in the venoms of colubrid snakes Boiga dendrophila and Boiga irregularis contain N-terminal pyroglutamate, we searched for QC in venom glands of both snakes. Here we report cDNA sequences of QC from brain and venom gland tissues of Boiga species. We propose that QC expressed in snake venom gland tissue plays a role in the N-terminal pyroglutamate formation of several snake venom toxins, indirectly contributing to venom potency. © 2006 Elsevier Ltd. All rights reserved. | Source Title: | Toxicon | URI: | http://scholarbank.nus.edu.sg/handle/10635/101684 | ISSN: | 00410101 | DOI: | 10.1016/j.toxicon.2006.05.013 |
| Appears in Collections: | Staff Publications |
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