Potential cancer gene therapy by baculoviral transduction

Abstract

Many different types of therapeutic genes, ranging from suicide genes, tumor suppressor genes, to genes encoding tumor-specific antigens, have been successfully delivered by insect baculoviral vectors to treat tumours in animal models. These encouraging results observed to date underscore the potential for using the non-human baculovirus to combat human cancer. The present review outlines the advances in this area and highlights the challenges behind translating the findings from research with baculoviral vectors into clinical practice. © 2010 Bentham Science Publishers Ltd.