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|Title:||miR-124 controls male reproductive success in Drosophila|
|Citation:||Weng, R., Chin, J.S.R., Yew, J.Y., Bushati, N., Cohen, S.M. (2013-06-11). miR-124 controls male reproductive success in Drosophila. eLife 2013 (2) : -. ScholarBank@NUS Repository. https://doi.org/10.7554/eLife.00640|
|Abstract:||Many aspects of social behavior are controlled by sex-specific pheromones. Genderappropriate production of the sexually dimorphic transcription factors doublesex and fruitless controls sexual differentiation and sexual behavior. miR-124 mutant males exhibited increased male-male courtship and reduced reproductive success with females. Females showed a strong preference for wild-type males over miR-124 mutant males when given a choice of mates. These effects were traced to aberrant pheromone production. We identified the sex-specific splicing factor transformer as a functionally significant target of miR-124 in this context, suggesting a role for miR-124 in the control of male sexual differentiation and behavior, by limiting inappropriate expression of the female form of transformer. miR-124 is required to ensure fidelity of genderappropriate pheromone production in males. Use of a microRNA provides a secondary means of controlling the cascade of sex-specific splicing events that controls sexual differentiation in Drosophila. Copyright Weng et al.|
|Appears in Collections:||Staff Publications|
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