Please use this identifier to cite or link to this item: https://doi.org/10.7554/eLife.00640
Title: miR-124 controls male reproductive success in Drosophila
Authors: Weng, R.
Chin, J.S.R.
Yew, J.Y. 
Bushati, N.
Cohen, S.M.
Issue Date: 11-Jun-2013
Source: Weng, R., Chin, J.S.R., Yew, J.Y., Bushati, N., Cohen, S.M. (2013-06-11). miR-124 controls male reproductive success in Drosophila. eLife 2013 (2) : -. ScholarBank@NUS Repository. https://doi.org/10.7554/eLife.00640
Abstract: Many aspects of social behavior are controlled by sex-specific pheromones. Genderappropriate production of the sexually dimorphic transcription factors doublesex and fruitless controls sexual differentiation and sexual behavior. miR-124 mutant males exhibited increased male-male courtship and reduced reproductive success with females. Females showed a strong preference for wild-type males over miR-124 mutant males when given a choice of mates. These effects were traced to aberrant pheromone production. We identified the sex-specific splicing factor transformer as a functionally significant target of miR-124 in this context, suggesting a role for miR-124 in the control of male sexual differentiation and behavior, by limiting inappropriate expression of the female form of transformer. miR-124 is required to ensure fidelity of genderappropriate pheromone production in males. Use of a microRNA provides a secondary means of controlling the cascade of sex-specific splicing events that controls sexual differentiation in Drosophila. Copyright Weng et al.
Source Title: eLife
URI: http://scholarbank.nus.edu.sg/handle/10635/101101
ISSN: 2050084X
DOI: 10.7554/eLife.00640
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

16
checked on Jan 17, 2018

WEB OF SCIENCETM
Citations

14
checked on Jan 17, 2018

Page view(s)

17
checked on Jan 12, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.