Please use this identifier to cite or link to this item: https://doi.org/10.1039/c3cc44880k
Title: Membrane destabilization by monomeric hIAPP observed by imaging fluorescence correlation spectroscopy
Authors: Bag, N.
Ali, A.
Chauhan, V.S.
Wohland, T. 
Mishra, A.
Issue Date: 14-Oct-2013
Source: Bag, N., Ali, A., Chauhan, V.S., Wohland, T., Mishra, A. (2013-10-14). Membrane destabilization by monomeric hIAPP observed by imaging fluorescence correlation spectroscopy. Chemical Communications 49 (80) : 9155-9157. ScholarBank@NUS Repository. https://doi.org/10.1039/c3cc44880k
Abstract: Monomeric hIAPP significantly destabilizes both model and live cell membranes by increasing membrane fluidity. This interaction with membranes happens via carpet formation followed by lipid extraction in a concentration dependent manner and thus we propose that hIAPP aggregation prior to membrane interaction may not be necessary for its cytotoxicity. © 2013 The Royal Society of Chemistry.
Source Title: Chemical Communications
URI: http://scholarbank.nus.edu.sg/handle/10635/101079
ISSN: 13597345
DOI: 10.1039/c3cc44880k
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