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https://scholarbank.nus.edu.sg/handle/10635/101079
| Title: | Membrane destabilization by monomeric hIAPP observed by imaging fluorescence correlation spectroscopy | Authors: | Bag, N. Ali, A. Chauhan, V.S. Wohland, T. Mishra, A. |
Issue Date: | 14-Oct-2013 | Citation: | Bag, N., Ali, A., Chauhan, V.S., Wohland, T., Mishra, A. (2013-10-14). Membrane destabilization by monomeric hIAPP observed by imaging fluorescence correlation spectroscopy. Chemical Communications 49 (80) : 9155-9157. ScholarBank@NUS Repository. | Abstract: | Monomeric hIAPP significantly destabilizes both model and live cell membranes by increasing membrane fluidity. This interaction with membranes happens via carpet formation followed by lipid extraction in a concentration dependent manner and thus we propose that hIAPP aggregation prior to membrane interaction may not be necessary for its cytotoxicity. © 2013 The Royal Society of Chemistry. | Source Title: | Chemical Communications | URI: | http://scholarbank.nus.edu.sg/handle/10635/101079 | ISSN: | 13597345 |
| Appears in Collections: | Staff Publications |
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