Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.toxicon.2004.03.012
Title: In vitro neuromuscular activity of 'colubrid' venoms: Clinical and evolutionary implications
Authors: Lumsden, N.G.
Fry, B.G.
Manjunatha Kini, R. 
Hodgson, W.C.
Keywords: Chick biventer cervicis
Colubroidea
Neostigmine
Neuromuscular
Venom
Issue Date: Jun-2004
Citation: Lumsden, N.G., Fry, B.G., Manjunatha Kini, R., Hodgson, W.C. (2004-06). In vitro neuromuscular activity of 'colubrid' venoms: Clinical and evolutionary implications. Toxicon 43 (7) : 819-827. ScholarBank@NUS Repository. https://doi.org/10.1016/j.toxicon.2004.03.012
Abstract: In this study, venoms from species in the Colubrinae, Homalopsinae, Natricinae, Pseudoxyrhophiinae and Psammophiinae snake families were assayed for activity in the chick biventer cervicis skeletal nerve muscle preparation. Boiga dendrophila, Boiga cynodon, Boiga dendrophila gemincincta, Boiga drapiezii, Boiga irregularis, Boiga nigriceps and Telescopus dhara venoms (10 μg/ml) displayed postsynaptic neuromuscular activity as evidenced by inhibition of indirect (0.1 Hz, 0.2 ms, supramaximal V) twitches. Neostigmine (5 μM) reversed the inhibition caused by B. cynodon venom (10 μg/ml) while the inhibitory effects of Psammophis mossambicus venom (10 μg/ml) spontaneously reversed, indicating a reversible mode of action for both venoms. Trimorphodon biscutatus (10 μg/ml) displayed irreversible presynaptic neurotoxic activity. Detectable levels of phospholipase A 2 activity were found only in T. biscutatus, T. dhara and P. mossambicus venoms. The results demonstrate a hitherto unsuspected diversity of pharmacological actions in all lineages which may have implications ranging from clinical management of envenomings to venom evolution. © 2004 Elsevier Ltd. All rights reserved.
Source Title: Toxicon
URI: http://scholarbank.nus.edu.sg/handle/10635/100902
ISSN: 00410101
DOI: 10.1016/j.toxicon.2004.03.012
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