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https://scholarbank.nus.edu.sg/handle/10635/100448
Title: | Dexamethasone receptors and their distribution in the brain of the red tilapia | Authors: | Chen, K.M. Chan, W.K. Munro, A.D. |
Keywords: | Brain Cortisol receptors Dexamethasone-binding Tilapia |
Issue Date: | 1997 | Citation: | Chen, K.M., Chan, W.K., Munro, A.D. (1997). Dexamethasone receptors and their distribution in the brain of the red tilapia. Fish Physiology and Biochemistry 16 (3) : 171-179. ScholarBank@NUS Repository. | Abstract: | Cytosolic extracts of liver and brain showed specific, saturable binding with [3H]dexamethasone: Scatchard plots were linear. Cortisol and 11-deoxycortisol acted as competitors, whilst 17α,20α-dihydroxy-4-pregnen-3-one was relatively much less effective. There was a four-fold range of differences in specific binding capacity between dissected brain regions, the order being telencephalon > hypothalamus > rhombencephalon > optic tectum ≈ (thalamus + tegmentum + torus semicircularis) when Nmax was calculated in terms of DNA content. There was no evidence for any binding of [3H]dexamethasone with membrane fractions. | Source Title: | Fish Physiology and Biochemistry | URI: | http://scholarbank.nus.edu.sg/handle/10635/100448 | ISSN: | 09201742 |
Appears in Collections: | Staff Publications |
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