Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/100210
Title: Cancer Chemopreventive Activity of Rotenoids from Derris trifoliata
Authors: Ito, C.
Itoigawa, M.
Kojima, N.
Tan, H.T.-W. 
Takayasu, J.
Tokuda, H.
Nishino, H.
Furukawa, H.
Keywords: Anti-tumor promoters
Cancer chemopreventive agents
Derris trifoliata
Leguminosae
Rotenoid
Issue Date: Jan-2004
Citation: Ito, C.,Itoigawa, M.,Kojima, N.,Tan, H.T.-W.,Takayasu, J.,Tokuda, H.,Nishino, H.,Furukawa, H. (2004-01). Cancer Chemopreventive Activity of Rotenoids from Derris trifoliata. Planta Medica 70 (1) : 8-11. ScholarBank@NUS Repository.
Abstract: A study of the chemical constituents of the stems of Derris trifoliata Lour. (Leguminosae) led to the isolation and identification of one new rotenoid, 6aα,12aα-12a-hydroxyelliptone (3), together with five other known rotenoids. In a search for novel cancer chemopreventive agents (anti-tumor promoters), we carried out a primary screening of five of the rotenoids isolated from the plant for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) in Raji cells. The inhibitory activity of 3 was found to be equivalent to that of β-carotene without any cytotoxicity. Deguelin (4) and α-toxicarol (5) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. This investigation indicated that rotenoids might be valuable anti-tumor promoters.
Source Title: Planta Medica
URI: http://scholarbank.nus.edu.sg/handle/10635/100210
ISSN: 00320943
Appears in Collections:Staff Publications

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