Please use this identifier to cite or link to this item: https://doi.org/10.1093/bioinformatics/18.12.1699
Title: ADME-AP: A database of ADME associated proteins
Authors: Sun, L.Z.
Ji, Z.L. 
Chen, X. 
Wang, J.F.
Chen, Y.Z. 
Issue Date: 1-Dec-2002
Citation: Sun, L.Z., Ji, Z.L., Chen, X., Wang, J.F., Chen, Y.Z. (2002-12-01). ADME-AP: A database of ADME associated proteins. Bioinformatics 18 (12) : 1699-1700. ScholarBank@NUS Repository. https://doi.org/10.1093/bioinformatics/18.12.1699
Abstract: Summary: Drug absorption, distribution, metabolism and excretion (ADME) often involve interaction of a drug with specific proteins. Knowledge about these ADME-associated proteins is important in facilitating the study of the molecular mechanism of disposition and individual response as well as therapeutic action of drugs. It is also useful in the development and testing of pharmacokinetics prediction tools. Several databases describing specific classes of ADME-associated proteins have appeared. A new database, ADME-associated proteins (ADME-AP), is introduced to provide comprehensive information about all classes of ADME-associated proteins described in the literature including physiological function of each protein, pharmacokinetic effect, ADME classification, direction and driving force of disposition, location and tissue distribution, substrates, synonyms, gene name and protein availability in other species. Cross-links to other databases are also provided to facilitate the access of information about the sequence, 3D structure, function, polymorphisms, genetic disorders, nomenclature, ligand binding properties and related literatures of each protein. ADME-AP currently contains entries for 321 proteins and 964 substrates.
Source Title: Bioinformatics
URI: http://scholarbank.nus.edu.sg/handle/10635/100014
ISSN: 13674803
DOI: 10.1093/bioinformatics/18.12.1699
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