Kostyuchenko, V.A.Zhang, Q.Tan, J.L.Ng, T.-S.Lok, S.-M.DUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE2016-06-012016-06-012013-07Kostyuchenko, V.A., Zhang, Q., Tan, J.L., Ng, T.-S., Lok, S.-M. (2013-07). Immature and mature dengue serotype 1 virus structures provide insight into the maturation process. Journal of Virology 87 (13) : 7700-7707. ScholarBank@NUS Repository. https://doi.org/10.1128/JVI.00197-130022538Xhttps://scholarbank.nus.edu.sg/handle/10635/124733Dengue virus is a major human pathogen that has four serotypes (DENV1 to -4). Here we report the cryoelectron microscopy (cryo-EM) structures of immature and mature DENV1 at 6- and 4.5-Å resolution, respectively. The subnanometer-resolution maps allow accurate placement of all of the surface proteins. Although the immature and mature viruses showed vastly different surface protein organizations, the envelope protein transmembrane (E-TM) regions remain in similar positions. The pivotal role of the E-TM regions leads to the identification of the start and end positions of all surface proteins during maturation. © 2013, American Society for Microbiology.Article000320116500043