Dou, X.Lu, Y.CHEMISTRY2014-10-162014-10-162012-07-02Dou, X., Lu, Y. (2012-07-02). Diastereodivergent synthesis of 3-spirocyclopropyl-2-oxindoles through direct enantioselective cyclopropanation of oxindoles. Chemistry - A European Journal 18 (27) : 8315-8319. ScholarBank@NUS Repository. https://doi.org/10.1002/chem.20120065509476539https://scholarbank.nus.edu.sg/handle/10635/93581Falling like dominos: The first direct organocatalytic asymmetric cyclopropanation reaction of oxindole was developed, in which oxindoles were employed as a dinucleophilic C 1 synthon and bromonitroolefins with a dielectrophilic center were used as a C 2 synthon (see scheme). An amino acid based multifunctional catalyst promoted the [2+1] reaction, giving the products in high yields and excellent enantioselectivities. A divergent synthesis of different stereoisomers of 3-spirocyclopropyl-2-oxindoles was achieved. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.asymmetric synthesiscyclopropanationdomino reactionsorganocatalysisoxindoleArticle000305560200010