Itahana, YItahana, KDUKE-NUS MEDICAL SCHOOL2020-10-302020-10-302018Itahana, Y, Itahana, K (2018). Emerging roles of p53 family members in glucose metabolism. International Journal of Molecular Sciences 19 (3) : 776. ScholarBank@NUS Repository. https://doi.org/10.3390/ijms1903077616616596https://scholarbank.nus.edu.sg/handle/10635/182088Glucose is the key source for most organisms to provide energy, as well as the key source for metabolites to generate building blocks in cells. The deregulation of glucose homeostasis occurs in various diseases, including the enhanced aerobic glycolysis that is observed in cancers, and insulin resistance in diabetes. Although p53 is thought to suppress tumorigenesis primarily by inducing cell cycle arrest, apoptosis, and senescence in response to stress, the non-canonical functions of p53 in cellular energy homeostasis and metabolism are also emerging as critical factors for tumor suppression. Increasing evidence suggests that p53 plays a significant role in regulating glucose homeostasis. Furthermore, the p53 family members p63 and p73, as well as gain-of-function p53 mutants, are also involved in glucose metabolism. Indeed, how this protein family regulates cellular energy levels is complicated and difficult to disentangle. This review discusses the roles of the p53 family in multiple metabolic processes, such as glycolysis, gluconeogenesis, aerobic respiration, and autophagy. We also discuss how the dysregulation of the p53 family in these processes leads to diseases such as cancer and diabetes. Elucidating the complexities of the p53 family members in glucose homeostasis will improve our understanding of these diseases. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/glucose transporter 3glucose transporter 4mitochondrial transcription factor Amonocarboxylate transporter 1protein p53protein p63sirtuin 1glucoseprotein p53TP63 protein, humantranscription factortumor protein p73tumor suppressor proteinautophagydephosphorylationdiabetes mellituselectron transportepigeneticsgluconeogenesisglucose metabolismglucose transportglycolysishumaninsulin releaseinsulin resistancemitochondrial respirationnonhumanoxidative phosphorylationpentose phosphate cycleprotein expressionReviewtranscription regulationanimalgeneticsglycolysismetabolismmutationAnimalsGlucoseGlycolysisHumansMutationTranscription FactorsTumor Protein p73Tumor Suppressor Protein p53Tumor Suppressor ProteinsReview