Timbadia, DhayanLer, AshlynnSazzad, FaizusAlexiou, ChristosKofidis, TheoSURGERY2020-10-122020-10-122020-07-22Timbadia, Dhayan, Ler, Ashlynn, Sazzad, Faizus, Alexiou, Christos, Kofidis, Theo (2020-07-22). FFR-guided versus coronary angiogram-guided CABG: A review and meta-analysis of prospective randomized controlled trials. JOURNAL OF CARDIAC SURGERY 35 (10). ScholarBank@NUS Repository. https://doi.org/10.1111/jocs.148800886044015408191https://scholarbank.nus.edu.sg/handle/10635/177370© 2020 Wiley Periodicals LLC Background: Fractional flow reserve (FFR) is a well-established method for the evaluation of coronary artery stenosis before percutaneous coronary intervention. However, whether FFR assessment should be routinely used before coronary artery bypass graft surgery (CABG) remains unclear. A meta-analysis of prospectively randomized controlled trials (PRCTs) was carried out to compare the outcomes of FFR-guided CABG vs coronary angiography (CAG)-guided CABG. Method: The meta-analysis adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Two PRCTs (the FARGO and GRAFFITI trials) were found and included reporting data on 269 patients with 6 and 12 month follow-up. Primary endpoints were rates of overall death, MACCE, target vessel revascularization, and spontaneous myocardial infarction (MI). Secondary endpoints were overall graft patency and patency of arterial and venous grafts. Results: There were no significant differences between the FFR-guided and CAG-guided groups in the rates of overall death, MACCE, target vessel revascularization, spontaneous MI and graft patency. Meta-analysis of FARGO and GRAFFITI PRCTs showed that FFR-guided CABG and CAG-guided CABG produced similar clinical outcomes with similar graft patency rates up to a year postoperatively. Conclusion: Currently available PRCTs showes no sufficient evidence to support the use FFR in CABG.enScience & TechnologyLife Sciences & BiomedicineCardiac & Cardiovascular SystemsSurgeryCardiovascular System & Cardiologycoronary angiographycoronary artery bypasscoronary artery diseasefractional flow reservemeta-analysisFRACTIONAL FLOW RESERVEBYPASS GRAFT-SURGERY5-YEAR FOLLOW-UPINTERVENTIONSEVERITYSTENOSISPATENCYReview2020-10-11