Götte, M.Yip, G.W.ANATOMY2015-09-072015-09-072006-11-01Götte, M., Yip, G.W. (2006-11-01). Heparanase, hyaluronan, and CD44 in cancers: A breast carcinoma perspective. Cancer Research 66 (21) : 10233-10237. ScholarBank@NUS Repository. https://doi.org/10.1158/0008-5472.CAN-06-146400085472https://scholarbank.nus.edu.sg/handle/10635/120695Glycosaminoglycans are major constituents of the cancer cell surface and the tumor stroma. The heparan sulfate degrading enzyme heparanase, hyaluronan, and its receptor CD44 are up-regulated in breast cancer, generating a microenvironment that promotes tumor progression and metastasis. Recent experimental and clinical evidence shows that heparanase, hyaluronan, and CD44 regulate cancer cell proliferation, migration, and invasion, as well as tumor-associated angiogenesis and are correlated with patient survival. These findings suggest that they may be used as prognostic factors and targets for breast cancer treatment. ©2006 American Association for Cancer Research.Review000241781600002