Yan, Z.Li, P.Akimoto, T.DUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE2016-11-162016-11-162007-07Yan, Z., Li, P., Akimoto, T. (2007-07). Transcriptional control of the Pgc-1α gene in skeletal muscle in vivo. Exercise and Sport Sciences Reviews 35 (3) : 97-101. ScholarBank@NUS Repository. https://doi.org/10.1097/JES.0b013e3180a0316900916331https://scholarbank.nus.edu.sg/handle/10635/130514Endurance exercise promotes mitochondrial biogenesis in skeletal muscle possibly by inducing peroxisome proliferator-activated receptor γ coactivator 1α gene transcription through activation of the p38 mitogen-activated protein kinase pathway. A novel imaging analysis revealed the importance of activating transcription factor 2 and histone deacetylase 5/myocyte enhancer factor 2 in the regulation of the Pgc-1α gene in skeletal muscle in vivo. ©2007The Amercian College of Sports Medicine.ExerciseFiber-type switchingMitochondrial biogenesisPeroxisome proliferator-activated receptor γ coactivator 1αSignal transductionSkeletal muscle adaptationReview000248090300003