Soria, B.Quesada, I.Ropero, A.B.Pertusa, J.A.Martín, F.Nada, A.SURGERY2014-11-202014-11-202004-02Soria, B.,Quesada, I.,Ropero, A.B.,Pertusa, J.A.,Martín, F.,Nada, A. (2004-02). Novel Players in Pancreatic Islet Signaling: From Membrane Receptors to Nuclear Channels. Diabetes 53 (SUPPL. 1) : S86-S91. ScholarBank@NUS Repository.00121797https://scholarbank.nus.edu.sg/handle/10635/108135Glucose and other nutrients regulate many aspects of pancreatic islet physiology. This includes not only insulin release, but also insulin synthesis and storage and other aspects of β-cell biology, including cell proliferation, apoptosis, differentiation, and gene expression. This implies that in addition to the well-described signals for insulin release, other intracellular signaling mechanisms are needed. Here we describe the role of global and local Ca 2+ signals in insulin release, the regulation of these signals by new membrane receptors, and the generation of nuclear Ca 2+ signals involved in gene expression. An integrated view of these pathways should improve the present description of the β-cell biology and provide new targets for novel drugs.Conference PaperNOT_IN_WOS