Please use this identifier to cite or link to this item: https://doi.org/10.1101/gad.1800409
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dc.titleA timing mechanism for stem cell maintenance and differentiation in the Arabidopsis floral meristem
dc.contributor.authorSun, B.
dc.contributor.authorXu, Y.
dc.contributor.authorNg, K.-H.
dc.contributor.authorIto, T.
dc.date.accessioned2014-10-27T08:20:40Z
dc.date.available2014-10-27T08:20:40Z
dc.date.issued2009-08-01
dc.identifier.citationSun, B., Xu, Y., Ng, K.-H., Ito, T. (2009-08-01). A timing mechanism for stem cell maintenance and differentiation in the Arabidopsis floral meristem. Genes and Development 23 (15) : 1791-1804. ScholarBank@NUS Repository. https://doi.org/10.1101/gad.1800409
dc.identifier.issn08909369
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/99979
dc.description.abstractDevelopmental regulation of the floral meristem ensures that plants of the same species have similarly sized flowers with a fixed number of floral organs. The maintenance of stem cells in the floral meristem is terminated after the production of a fixed number of floral organ primordia. Precise repression of the Arabidopsis thaliana homeobox gene WUSCHEL (WUS) by the floral homeotic protein AGAMOUS (AG) plays a major part in this process. Here we show that KNUCKLES (KNU) mediates the repression of WUS in floral meristem determinacy control. AG directly induces the transcription of KNU, which encodes a C2H2-type zinc finger protein with a conserved transcriptional repression motif. In turn, KNU represses WUS transcription to abolish stem cell activity. We also show that the timing of KNU induction is key in balancing proliferation and differentiation in flower development. Delayed KNU expression results in an indeterminate meristem, whereas ectopic KNU expression prematurely terminates the floral meristem. Furthermore, KNU induction by AG is preceded by changes in repressive histone modification at the KNU locus, which occurs in an AG-dependent manner. This study provides a mechanistic link between transcriptional feedback and epigenetic regulation in plant stem cell proliferation. © 2009 by Cold Spring Harbor Laboratory Press.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1101/gad.1800409
dc.sourceScopus
dc.subjectAGAMOUS
dc.subjectArabidopsis thaliana
dc.subjectFlower development
dc.subjectHomeotic control
dc.subjectMADS protein
dc.subjectStem cell
dc.subjectWUSCHEL
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1101/gad.1800409
dc.description.sourcetitleGenes and Development
dc.description.volume23
dc.description.issue15
dc.description.page1791-1804
dc.description.codenGEDEE
dc.identifier.isiut000268598600010
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