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Title: A small peptide derived from Flt-1 (VEGFR-1) functions as an angiogenic inhibitor
Authors: Tan, D.C.W.
Kini, R.Manjunatha 
Jois, S.D.S. 
Lim, D.K.F.
Xin, L.
Ge, R. 
Keywords: Angiogenesis
Chick chorioallantoic membrane
Miles' assay
Vascular endothelial growth factor (vascular permeability factor)
Issue Date: 13-Apr-2001
Citation: Tan, D.C.W., Kini, R.Manjunatha, Jois, S.D.S., Lim, D.K.F., Xin, L., Ge, R. (2001-04-13). A small peptide derived from Flt-1 (VEGFR-1) functions as an angiogenic inhibitor. FEBS Letters 494 (3) : 150-156. ScholarBank@NUS Repository.
Abstract: Vascular endothelial growth factor (VEGF) is an angiogenic stimulator which functions through two endothelial specific tyrosine kinase receptors, Flt-1 and Flk-1. In this work, we show that an 11-amino acid peptide derived from the second immunoglobulin-like domain of Flt-1 functions as an angiogenic inhibitor in chick chorioallantoic membrane and inhibited VEGF-induced vascular permeability in Miles' assay without binding to VEGF directly. Circular dichroism and nuclear magnetic resonance analyses indicate that this peptide forms a stable extended structure in solution, presumably β-sheet structure and is most likely existing as a dimer. Our results suggest that this small peptide functions as an angiogenic inhibitor by inhibiting VEGF function through a non-VEGF binding mechanism. © 2001 Federation of European Biochemical Societies.
Source Title: FEBS Letters
ISSN: 00145793
DOI: 10.1016/S0014-5793(01)02314-6
Appears in Collections:Staff Publications

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