Please use this identifier to cite or link to this item: https://doi.org/10.1038/ismej.2007.76
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dc.titleA novel DSF-like signal from Burkholderia cenocepacia interferes with Candida albicans morphological transition
dc.contributor.authorBoon, C.
dc.contributor.authorDeng, Y.
dc.contributor.authorWang, L.-H.
dc.contributor.authorHe, Y.
dc.contributor.authorXu, J.-L.
dc.contributor.authorFan, Y.
dc.contributor.authorPan, S.Q.
dc.contributor.authorZhang, L.-H.
dc.date.accessioned2014-10-27T08:20:01Z
dc.date.available2014-10-27T08:20:01Z
dc.date.issued2008-01
dc.identifier.citationBoon, C., Deng, Y., Wang, L.-H., He, Y., Xu, J.-L., Fan, Y., Pan, S.Q., Zhang, L.-H. (2008-01). A novel DSF-like signal from Burkholderia cenocepacia interferes with Candida albicans morphological transition. ISME Journal 2 (1) : 27-36. ScholarBank@NUS Repository. https://doi.org/10.1038/ismej.2007.76
dc.identifier.issn17517362
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/99918
dc.description.abstractIn addition to producing lethal antibiotics, microorganisms may also use a new form of antagonistic mechanism in which signal molecules are exported to influence the gene expression and hence the ecological competence of their competitors. We report here the isolation and characterization of a novel signaling molecule, cis-2-dodecenoic acid (BDSF), from Burkholderia cenocepacia. BDSF is structurally similar to the diffusible signal factor (DSF) that is produced by the RpfF enzyme of Xanthomonas campestris. Deletion analysis demonstrated that Bcam0581, which encodes an RpfF homologue, was essential for BDSF production. The gene is highly conserved and widespread in the Burkholderia cepacia complex. Exogenous addition of BDSF restored the biofilm and extracellular polysaccharide production phenotypes of Xanthomonas campestris pv. campestris DSF-deficient mutants, highlighting its potential role in inter-species signaling. Further analyses showed that Candida albicans germ tube formation was strongly inhibited by either coculture with B. cenocepacia or by exogenous addition of physiological relevant levels of BDSF, whereas deletion of Bcam0581 abrogated the inhibitory ability of the bacterial pathogen. As B. cenocepacia and C. albicans are frequently encountered human pathogens, identification of the BDSF signal and its activity thus provides a new insight into the molecular grounds of their antagonistic interactions whose importance to microbial ecology and pathogenesis is now becoming evident. © 2008 International Society for Microbial Ecology All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1038/ismej.2007.76
dc.sourceScopus
dc.subjectAntagonism
dc.subjectBDSF
dc.subjectDSF
dc.subjectQuorum sensing
dc.subjectSignal interference
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1038/ismej.2007.76
dc.description.sourcetitleISME Journal
dc.description.volume2
dc.description.issue1
dc.description.page27-36
dc.identifier.isiut000252592100004
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