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Title: A bacterial cell-cell communication signal with cross-kingdom structural analogues
Authors: Wang, L.-H.
He, Y.
Gao, Y.
Wu, J.E.
Dong, Y.-H.
He, C.
Wang, S.X.
Weng, L.-X.
Xu, J.-L.
Tay, L.
Fang, R.X.
Zhang, L.-H. 
Issue Date: Feb-2004
Citation: Wang, L.-H., He, Y., Gao, Y., Wu, J.E., Dong, Y.-H., He, C., Wang, S.X., Weng, L.-X., Xu, J.-L., Tay, L., Fang, R.X., Zhang, L.-H. (2004-02). A bacterial cell-cell communication signal with cross-kingdom structural analogues. Molecular Microbiology 51 (3) : 903-912. ScholarBank@NUS Repository.
Abstract: Extracellular signals are the key components of microbial cell-cell communication systems. This report identified a diffusible signal factor (DSF), which regulates virulence in Xanthomonas campestris pv. campestris, as cis-11-methyl-2-dodecenoic acid, an α,β unsaturated fatty acid. Analysis of DSF derivatives established the double bond at the α,β positions as the most important structural feature for DSF biological activity. A range of bacterial pathogens, including several Mycobacterium species, also displayed DSF-like activity. Furthermore, DSF is structurally and functionally related to farnesoic acid (FA), which regulates morphological transition and virulence by Candida albicans, a fungal pathogen. Similar to FA, which is also an α,β unsaturated fatty acid, DSF inhibits the dimorphic transition of C. albicans at a physiologically relevant concentration. We conclude that α,β unsaturated fatty acids represent a new class of extracellular signals for bacterial and fungal cell-cell communications. As prokaryote-eukaryote interactions are ubiquitous, such cross-kingdom conservation in cell-cell communication systems might have significant ecological and economic importance.
Source Title: Molecular Microbiology
ISSN: 0950382X
DOI: 10.1046/j.1365-2958.2003.03883.x
Appears in Collections:Staff Publications

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