Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.nimb.2005.01.092
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dc.titleMeasurement of cell motility on proton beam micromachined 3D scaffolds
dc.contributor.authorZhang, F.
dc.contributor.authorSun, F.
dc.contributor.authorVan Kan, J.A.
dc.contributor.authorShao, P.G.
dc.contributor.authorZheng, Z.
dc.contributor.authorGe, R.W.
dc.contributor.authorWatt, F.
dc.date.accessioned2014-10-16T09:51:29Z
dc.date.available2014-10-16T09:51:29Z
dc.date.issued2005-04
dc.identifier.citationZhang, F., Sun, F., Van Kan, J.A., Shao, P.G., Zheng, Z., Ge, R.W., Watt, F. (2005-04). Measurement of cell motility on proton beam micromachined 3D scaffolds. Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms 231 (1-4) : 413-418. ScholarBank@NUS Repository. https://doi.org/10.1016/j.nimb.2005.01.092
dc.identifier.issn0168583X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/98791
dc.description.abstractTissue engineering is a rapidly developing and highly interdisciplinary field that applies the principles of cell biology, engineering and material science. In natural tissues, the cells are arranged in a three-dimensional (3D) matrix which provides the appropriate functional, nutritional and spatial conditions. In scaffold guided tissue engineering 3D scaffolds provide the critical function of acting as extracellular matrices onto which cells can attach, grow, and form new tissue. The main focus of this paper is to understand cell behavior on micro-grooved and ridged substrates and to study the effects of geometrical constraints on cell motility and cell function. In this study, we found that BAE (Bovine Aortic Endothelial) cells naturally align with and are guided along 3D ridges and grooves machined into polymethylmethacrylate (PMMA) substrates. Average cell speed on micro-grooves and ridges ranged from 0.015 μm/s (for 12 μm wide and 10 μm deep ridges) to 0.025 μm/s (for 20 μm wide and 10 μm deep ridges). This compares with the cell motility rate on a flat PMMA surface where the average cell speed is around 0.012 μm/s. In this work we used scaffolds which were directly written with a focused proton beam, typically 1 MeV protons with a beam spot size of 1 × 1 μm 2. © 2005 Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.nimb.2005.01.092
dc.sourceScopus
dc.subject3D scaffolds
dc.subjectCell guidance
dc.subjectCell motility
dc.subjectProton beam writing
dc.typeConference Paper
dc.contributor.departmentPHYSICS
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1016/j.nimb.2005.01.092
dc.description.sourcetitleNuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms
dc.description.volume231
dc.description.issue1-4
dc.description.page413-418
dc.description.codenNIMBE
dc.identifier.isiut000229752400069
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