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Title: Traffic of single-headed motor proteins KIF1A: Effects of lane changing
Authors: Chowdhury, D.
Garai, A.
Wang, J.-S. 
Issue Date: 12-May-2008
Citation: Chowdhury, D., Garai, A., Wang, J.-S. (2008-05-12). Traffic of single-headed motor proteins KIF1A: Effects of lane changing. Physical Review E - Statistical, Nonlinear, and Soft Matter Physics 77 (5) : -. ScholarBank@NUS Repository.
Abstract: KIF1A kinesins are single-headed motor proteins which move on cylindrical nanotubes called microtubules (MTs). A normal MT consists of 13 protofilaments on which the equispaced motor binding sites form a periodic array. The collective movement of the kinesins on a MT is, therefore, analogous to vehicular traffic on multilane highways where each protofilament is the analog of a single lane. Does lane changing increase or decrease the motor flux per lane? We address this fundamental question here by appropriately extending a recent model. By carrying out analytical calculations and computer simulations of this extended model, we predict that the flux per lane can increase or decrease with the increasing rate of lane changing, depending on the concentrations of motors and the rate of hydrolysis of ATP, the "fuel" molecules. Our predictions can be tested, in principle, by carrying out in vitro experiments with fluorescently labeled KIF1A molecules. © 2008 The American Physical Society.
Source Title: Physical Review E - Statistical, Nonlinear, and Soft Matter Physics
ISSN: 15393755
DOI: 10.1103/PhysRevE.77.050902
Appears in Collections:Staff Publications

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