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Title: Principles of mimicking and engineering the self-organized structure of hard tissues
Authors: Jiang, H. 
Liu, X.-Y. 
Issue Date: 1-Oct-2004
Citation: Jiang, H., Liu, X.-Y. (2004-10-01). Principles of mimicking and engineering the self-organized structure of hard tissues. Journal of Biological Chemistry 279 (40) : 41286-41293. ScholarBank@NUS Repository.
Abstract: The mechanism of the formation of a self-aligned hydroxyapatite (HAP) nanocrystallite structure was examined. It is found that the highly ordered HAP nanocrystallite assembly is attributed to the so-called self-(homo)epitaxial nucleation and growth. On the other hand, according to this mechanism, a high supersaturation will give rise to a random assembly of HAP crystallites. The effects of ions, biosubstrate, and supersaturation on the micro/nanostructure correlation between substrate and biominerals as well as their implications in hard tissue formation were examined. Surprisingly, some biomolecules are found to be able to suppress the supersaturation-driven interfacial structure mismatch and hence promote the well aligned HAP pattern formation.
Source Title: Journal of Biological Chemistry
ISSN: 00219258
DOI: 10.1074/jbc.M314027200
Appears in Collections:Staff Publications

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