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Title: Nuclear microscopy in Parkinson's disease
Authors: Watt, F. 
Lee, T.
Thong, P.S.P. 
Tang, S.M. 
Issue Date: 2-Sep-1995
Citation: Watt, F.,Lee, T.,Thong, P.S.P.,Tang, S.M. (1995-09-02). Nuclear microscopy in Parkinson's disease. Nuclear Inst. and Methods in Physics Research, B 104 (1-4) : 361-364. ScholarBank@NUS Repository.
Abstract: Rats have been subjected to unilateral lesioning with the selective neurotoxin 6-OHDA in order to induce Parkinsonism. Analysis using the NUS Nuclear Microscope facility have shown that iron levels are raised by an average of 26% in the lesioned subtantia nigra region of the brain compared with the non-lesioned side. In addition the background tissue level of iron is also elevated by 31% in the lesioned side, indicating that there is a general increase in iron levels as a result of the lesioning. This result is consistent with the other observations that other diseases of the brain are frequently associated with altered iron levels (eg. progressive nuclear palsy, multiple system atrophy, Alzheimers disease, multiple sclerosis). © 1995.
Source Title: Nuclear Inst. and Methods in Physics Research, B
ISSN: 0168583X
Appears in Collections:Staff Publications

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