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Title: Maximum directionality and systematic classification of molecular motors
Authors: Efremov, A. 
Wang, Z. 
Issue Date: 21-Mar-2011
Citation: Efremov, A., Wang, Z. (2011-03-21). Maximum directionality and systematic classification of molecular motors. Physical Chemistry Chemical Physics 13 (11) : 5159-5170. ScholarBank@NUS Repository.
Abstract: Track-walking molecular motors are widely used in living cells for transport purposes, and artificial mimics are being vigorously pursued in engineered molecular systems. The defining character for a motor is its intrinsic capability to utilize energy input to rectify a sustained directional motion out of stochastic thermal motion. The energy injection can be coupled to a motor's mechanical steps in different ways, leading to different motor mechanisms. We derive here a formulation for maximum motor performance in terms of a new quantity called directionality based on a general representation of the track-walking motors. Compared to performance measures like velocity and processivity, directionality is a cleaner and more robust indicator of the rectification mechanism that amounts to a motor's inner design/working principles. Meaningful and distinctly different upper limits of directionality were found to exist for a wide variety of experimentally demonstrated and theoretically proposed motors and their biological counterparts. The maximum directionality provides a conceptual framework by which all of these different motors were quantitatively compared and systematically classified according to their mechanistic advancement. The results yield a series of guidelines for artificial motor development, and expose important evolutionary traits of biomotors. © the Owner Societies 2011.
Source Title: Physical Chemistry Chemical Physics
ISSN: 14639076
DOI: 10.1039/c0cp02519d
Appears in Collections:Staff Publications

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