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Title: Graphene for controlled and accelerated osteogenic differentiation of human mesenchymal stem cells
Authors: Nayak, T.R.
Andersen, H. 
Makam, V.S.
Khaw, C.
Bae, S.
Xu, X. 
Ee, P.-L.R. 
Ahn, J.-H.
Hong, B.H.
Pastorin, G. 
Özyilmaz, B. 
Keywords: bone
cell differentiation
mesenchymal stem cells
Issue Date: 28-Jun-2011
Citation: Nayak, T.R., Andersen, H., Makam, V.S., Khaw, C., Bae, S., Xu, X., Ee, P.-L.R., Ahn, J.-H., Hong, B.H., Pastorin, G., Özyilmaz, B. (2011-06-28). Graphene for controlled and accelerated osteogenic differentiation of human mesenchymal stem cells. ACS Nano 5 (6) : 4670-4678. ScholarBank@NUS Repository.
Abstract: Current tissue engineering approaches combine different scaffold materials with living cells to provide biological substitutes that can repair and eventually improve tissue functions. Both natural and synthetic materials have been fabricated for transplantation of stem cells and their specific differentiation into muscles, bones, and cartilages. One of the key objectives for bone regeneration therapy to be successful is to direct stem cells proliferation and to accelerate their differentiation in a controlled manner through the use of growth factors and osteogenic inducers. Here we show that graphene provides a promising biocompatible scaffold that does not hamper the proliferation of human mesenchymal stem cells (hMSCs) and accelerates their specific differentiation into bone cells. The differentiation rate is comparable to the one achieved with common growth factors, demonstrating graphenes potential for stem cell research. © 2011 American Chemical Society.
Source Title: ACS Nano
ISSN: 19360851
DOI: 10.1021/nn200500h
Appears in Collections:Staff Publications

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