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Title: Electrochemical genosensing properties of gold nanoparticle-carbon nanotube hybrid
Authors: Lim, S.H.
Wei, J. 
Lin, J. 
Issue Date: 21-Dec-2004
Citation: Lim, S.H., Wei, J., Lin, J. (2004-12-21). Electrochemical genosensing properties of gold nanoparticle-carbon nanotube hybrid. Chemical Physics Letters 400 (4-6) : 578-582. ScholarBank@NUS Repository.
Abstract: We have investigated the electrochemical genosensing properties of gold nanoparticle-carbon nanotube hybrid. Thiolated oligonucleotide probes and mercaptohexanol were self-assembled onto the Au-CNT hybrid. The hybridization events of target oligonucleotides are monitored using electrochemical impedance spectroscopy, cyclic voltammetry and a.c. voltammetry techniques. A redox-active mediator Ru(bpy) 3 2+ is used to detect the oxidation of guanine residues. The as-fabricated genosensor is able to differentiate between complementary and mismatched hybridizations, relying on the oxidation current of the guanine residues mediated via Ru(bpy) 3 2+. © 2004 Elsevier B.V. All rights reserved.
Source Title: Chemical Physics Letters
ISSN: 00092614
DOI: 10.1016/j.cplett.2004.11.023
Appears in Collections:Staff Publications

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