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Title: Effective degree network disease models
Authors: Lindquist, J.
Ma, J.
van den Driessche, P.
Willeboordse, F.H. 
Keywords: Basic reproduction number
SIR disease model
SIS disease model
Issue Date: Feb-2011
Citation: Lindquist, J., Ma, J., van den Driessche, P., Willeboordse, F.H. (2011-02). Effective degree network disease models. Journal of Mathematical Biology 62 (2) : 143-164. ScholarBank@NUS Repository.
Abstract: An effective degree approach to modeling the spread of infectious diseases on a network is introduced and applied to a disease that confers no immunity (a Susceptible-Infectious-Susceptible model, abbreviated as SIS) and to a disease that confers permanent immunity (a Susceptible-Infectious-Recovered model, abbreviated as SIR). Each model is formulated as a large system of ordinary differential equations that keeps track of the number of susceptible and infectious neighbors of an individual. From numerical simulations, these effective degree models are found to be in excellent agreement with the corresponding stochastic processes of the network on a random graph, in that they capture the initial exponential growth rates, the endemic equilibrium of an invading disease for the SIS model, and the epidemic peak for the SIR model. For each of these effective degree models, a formula for the disease threshold condition is derived. The threshold parameter for the SIS model is shown to be larger than that derived from percolation theory for a model with the same disease and network parameters, and consequently a disease may be able to invade with lower transmission than predicted by percolation theory. For the SIR model, the threshold condition is equal to that predicted by percolation theory. Thus unlike the classical homogeneous mixing disease models, the SIS and SIR effective degree models have different disease threshold conditions. © 2010 Springer-Verlag.
Source Title: Journal of Mathematical Biology
ISSN: 03036812
DOI: 10.1007/s00285-010-0331-2
Appears in Collections:Staff Publications

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