Please use this identifier to cite or link to this item: https://doi.org/10.1021/nl203114f
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dc.titleEffect of nanochannel geometry on DNA structure in the presence of macromolecular crowding agent
dc.contributor.authorJones, J.J.
dc.contributor.authorVan Der Maarel, J.R.C.
dc.contributor.authorDoyle, P.S.
dc.date.accessioned2014-10-16T09:22:06Z
dc.date.available2014-10-16T09:22:06Z
dc.date.issued2011-11-09
dc.identifier.citationJones, J.J., Van Der Maarel, J.R.C., Doyle, P.S. (2011-11-09). Effect of nanochannel geometry on DNA structure in the presence of macromolecular crowding agent. Nano Letters 11 (11) : 5047-5053. ScholarBank@NUS Repository. https://doi.org/10.1021/nl203114f
dc.identifier.issn15306984
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/96325
dc.description.abstractWe experimentally and numerically study the effects of macromolecular crowding agents on DNA structure when confined to a nanochannel. Curiously, DNA response to crowding is significantly different between bulk phase, nanoslit confinement, and nanotube confinement. Coarse grained Brownian dynamics simulations reproduce trends seen in the experiments and allow us to develop a deeper understanding of the key physics at play in these systems. It is proposed that the occupancy of free volume next to the channel wall by crowders causes an effective reduction in confining dimensions of the channel that initially swells DNA in nanoconfinement. © 2011 American Chemical Society.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1021/nl203114f
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentPHYSICS
dc.description.doi10.1021/nl203114f
dc.description.sourcetitleNano Letters
dc.description.volume11
dc.description.issue11
dc.description.page5047-5053
dc.identifier.isiut000296674700093
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