Please use this identifier to cite or link to this item:
|Title:||Comprehensive physical mechanism of two-headed biomotor myosin v||Authors:||Xu, Y.
|Issue Date:||2009||Citation:||Xu, Y., Wang, Z. (2009). Comprehensive physical mechanism of two-headed biomotor myosin v. Journal of Chemical Physics 131 (24) : -. ScholarBank@NUS Repository. https://doi.org/10.1063/1.3276283||Abstract:||Two-headed biomotor myosin V autonomously coordinates its two identical heads in fuel consumption and mechanical stepping, so that the dimerized motor as a whole gains the capability of processive, unidirectional movement along cytoskeletal filament. How the dimer-level functions like sustained direction rectification and autonomous coordination emerge out of physical principles poses an outstanding question pertinent to motor protein biology as well as the nascent field of bioinspired nanomotors. Here the comprehensive physical mechanism for myosin V motor is identified by a dimer-level free-energy analysis that is methodologically calibrated against experimental data. A hallmark of the identified mechanism is a mechanically mediated symmetry breaking that occurs at the dimer level and prevails against ubiquitous thermal fluctuations. Another character is the onset of substantial free-energy gaps between major dimer-track binding configurations. The symmetry breaking is the basis for myosin V's directional rectification, and the energy gaps facilitate autonomous head-head coordination. The mechanism explains the experimental finding that myosin V makes ATP-independent consecutive steps under high opposing loads but not under pushing loads. Interestingly, myosin V and another major biomotor kinesin 1 are found to share essentially the same core mechanism but for distinctly different working regimes. © 2009 American Institute of Physics.||Source Title:||Journal of Chemical Physics||URI:||http://scholarbank.nus.edu.sg/handle/10635/96054||ISSN:||00219606||DOI:||10.1063/1.3276283|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 21, 2020
WEB OF SCIENCETM
checked on Feb 13, 2020
checked on Feb 16, 2020
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.