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Title: Compaction dynamics of single DNA molecules under tension
Authors: Fu, W.-B.
Wang, X.-L.
Zhang, X.-H.
Ran, S.-Y.
Yan, J. 
Li, M.
Issue Date: 29-Nov-2006
Citation: Fu, W.-B., Wang, X.-L., Zhang, X.-H., Ran, S.-Y., Yan, J., Li, M. (2006-11-29). Compaction dynamics of single DNA molecules under tension. Journal of the American Chemical Society 128 (47) : 15040-15041. ScholarBank@NUS Repository.
Abstract: Using transverse magnetic tweezers, we studied the dynamics of DNA compaction induced by hexaammine cobalt chloride under constant forces. Discontinuous DNA compaction events were found for forces ranging from 0.5 to 1.7 pN, with ∼270 nm DNA adsorbed in each compaction event. Forces larger than 6 pN were found able to unravel the toroid in a similar intermittent stepwise manner. The observations indicate that the folding/unfolding events are transitions between two metastable structural states which are separated by a tension-dependent energy barrier. Analysis of the waiting time revealed that the degree of the package ordering of DNA in a toroid depends on the compaction kinetics. Copyright © 2006 American Chemical Society.
Source Title: Journal of the American Chemical Society
ISSN: 00027863
DOI: 10.1021/ja064305a
Appears in Collections:Staff Publications

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