Please use this identifier to cite or link to this item: https://doi.org/10.1039/c0an00943a
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dc.titleAn effective real-time colorimeteric sensor for sensitive and selective detection of cysteine under physiological conditions
dc.contributor.authorYan, Z.
dc.contributor.authorGuang, S.
dc.contributor.authorXu, H.
dc.contributor.authorLiu, X.
dc.date.accessioned2014-10-16T09:15:30Z
dc.date.available2014-10-16T09:15:30Z
dc.date.issued2011-05-07
dc.identifier.citationYan, Z., Guang, S., Xu, H., Liu, X. (2011-05-07). An effective real-time colorimeteric sensor for sensitive and selective detection of cysteine under physiological conditions. Analyst 136 (9) : 1916-1921. ScholarBank@NUS Repository. https://doi.org/10.1039/c0an00943a
dc.identifier.issn00032654
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/95760
dc.description.abstractIn this contribution, a new, real-time and sensitive colorimetric sensor, di-N-methyl-N-hydroxyethylaniline squaraine (SQ), has been identified and synthesized for cysteine analysis based on its ΔA in neutral aqueous medium (pH ≈ 7.5). The proposed method was applied to analyse synthetic amino acid samples and human serum samples. The results show that the linear range of cysteine detection in aqueous medium at pH ≈ 7.5 is 10∼700 nmol L -1 with a correlation coefficient (R) of 0.9984 and a limit of detection (3σ, n = 20) of 3.9 nmol L-1. The relative standard deviation (RSD) for cysteine detection was lower than 4.1% (n = 5). The proposed method possesses the advantages of simplicity, rapidity, high selectivity and sensitivity. This makes it possible, for the first time, the real-time detection of cysteine under normal physiological conditions. © 2011 The Royal Society of Chemistry.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1039/c0an00943a
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentPHYSICS
dc.description.doi10.1039/c0an00943a
dc.description.sourcetitleAnalyst
dc.description.volume136
dc.description.issue9
dc.description.page1916-1921
dc.description.codenANALA
dc.identifier.isiut000289365100020
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