Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/95680
DC FieldValue
dc.titleA review on terpenes as skin penetration enhancers in transdermal drug delivery
dc.contributor.authorLim, P.F.C.
dc.contributor.authorLiu, X.Y.
dc.contributor.authorChan, S.Y.
dc.date.accessioned2014-10-16T09:14:33Z
dc.date.available2014-10-16T09:14:33Z
dc.date.issued2009-09
dc.identifier.citationLim, P.F.C.,Liu, X.Y.,Chan, S.Y. (2009-09). A review on terpenes as skin penetration enhancers in transdermal drug delivery. Journal of Essential Oil Research 21 (5) : 423-428. ScholarBank@NUS Repository.
dc.identifier.issn10412905
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/95680
dc.description.abstractThe skin itself hinders the widespread use of transdermal drug delivery (TDD) for administration of medication. Despite the different strategies devised and employed to reversibly overcome the skin barrier, this non-invasive delivery mode is restricted to potent, low molar mass therapeutic agents. The use of chemical penetration enhancers is the conventional approach to modify the skin structure and lower its resistance for increased drug permeation. Over the years, extensive screening and testing have identified different classes of chemicals as potential adjuvants. Among these, terpenes (constituents of plant essential oils) have been widely investigated as skin penetration enhancers for both hydrophilic and hydrophobic drugs. In particular, monoterpenes were generally more efficacious probably due to their small molecular sizes. The main mechanisms of action of terpenes on the skin as determined by several analytical techniques were lipid extraction and phase separation. Terpenes such as limonene and menthol in experimental patch formulations were demonstrated to be safe on the skin and effective in improving drug delivery across the skin. © 2009 Allured Business Media.
dc.sourceScopus
dc.subjectPenetration enhancers
dc.subjectSkin penetration
dc.subjectTerpenes
dc.subjectTransdermal drug delivery
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.contributor.departmentPHYSICS
dc.description.sourcetitleJournal of Essential Oil Research
dc.description.volume21
dc.description.issue5
dc.description.page423-428
dc.description.codenJEORE
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

Page view(s)

53
checked on May 11, 2019

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.