Please use this identifier to cite or link to this item: https://doi.org/10.1046/j.1471-4159.1999.721574.x
DC FieldValue
dc.titleA nuclear microscopic study of elemental changes in the rat hippocampus after kainate-induced neuronal injury
dc.contributor.authorOng, W.-Y.
dc.contributor.authorRen, M.-Q.
dc.contributor.authorMakjanić, J.
dc.contributor.authorLim, T.-M.
dc.contributor.authorWatt, F.
dc.date.accessioned2014-10-16T09:14:23Z
dc.date.available2014-10-16T09:14:23Z
dc.date.issued1999
dc.identifier.citationOng, W.-Y., Ren, M.-Q., Makjanić, J., Lim, T.-M., Watt, F. (1999). A nuclear microscopic study of elemental changes in the rat hippocampus after kainate-induced neuronal injury. Journal of Neurochemistry 72 (4) : 1574-1579. ScholarBank@NUS Repository. https://doi.org/10.1046/j.1471-4159.1999.721574.x
dc.identifier.issn00223042
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/95665
dc.description.abstractThe effect of intracerebroventricular kainate injection on the elemental composition of the hippocampus was studied in adult Wistar rats, at 1 day and 1, 2, 3, and 4 weeks postinjection, using a nuclear microscope. An increase in calcium concentration was observed on the injected side from 1 day postinjection. The increase peaked at 3 weeks postinjection, reaching a concentration of 18 times normal. Large numbers of glial cells but no neurons were observed in the lesioned CA fields at this time, suggesting that an increased calcium level was present in glial cells. This was confirmed by high-resolution elemental maps of the lesioned areas, which showed very high intracellular calcium concentrations in almost all glial cells. It is possible that the high intracellular calcium level could activate calcium- dependent enzymes, including calpain II and cytosolic phospholipase A2, shown to be expressed in reactive glial cells after kainate injections. In addition to calcium, an increase in iron content was also observed at the periphery of the glial scar at 4 weeks postinjection. Because free iron could catalyze the formation of free radicals, the late increase in iron content may be related to oxygen radical formation during neurodegeneration.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1046/j.1471-4159.1999.721574.x
dc.sourceScopus
dc.subjectAlzheimer's disease
dc.subjectAstrocytes
dc.subjectCalcium
dc.subjectExcitotoxicity
dc.subjectMacrophages
dc.subjectNuclear microscope
dc.typeArticle
dc.contributor.departmentPHYSICS
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1046/j.1471-4159.1999.721574.x
dc.description.sourcetitleJournal of Neurochemistry
dc.description.volume72
dc.description.issue4
dc.description.page1574-1579
dc.description.codenJONRA
dc.identifier.isiut000079204300030
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

42
checked on May 18, 2022

WEB OF SCIENCETM
Citations

36
checked on May 18, 2022

Page view(s)

199
checked on May 12, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.