Please use this identifier to cite or link to this item:
https://doi.org/10.1021/cr200355j
DC Field | Value | |
---|---|---|
dc.title | Combinatorial strategies in fluorescent probe development | |
dc.contributor.author | Vendrell, M. | |
dc.contributor.author | Zhai, D. | |
dc.contributor.author | Er, J.C. | |
dc.contributor.author | Chang, Y.-T. | |
dc.date.accessioned | 2014-10-16T08:49:12Z | |
dc.date.available | 2014-10-16T08:49:12Z | |
dc.date.issued | 2012-08-08 | |
dc.identifier.citation | Vendrell, M., Zhai, D., Er, J.C., Chang, Y.-T. (2012-08-08). Combinatorial strategies in fluorescent probe development. Chemical Reviews 112 (8) : 4391-4420. ScholarBank@NUS Repository. https://doi.org/10.1021/cr200355j | |
dc.identifier.issn | 00092665 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/95552 | |
dc.description.abstract | Studies relating to the role of combinatorial and high-throughput strategies in the development of fluorescent probes during the last five years, mainly as a result of the expansion of combinatorial chemistry on fluorescent scaffolds and the major improvements in high-throughput screenings and imaging methodologies, are discussed. A group of Lu has engineered libraries of catalytic DNA to prepare sensors for Pb2+ and Zn2+ ions. Chang and co-workers reported a diversity-oriented fluorescent library for the development of photostable near-infrared (NIR) dyes and derivatized a tricarbocyanine structure by nucleophilic substitution with 80 amines and subsequent acetylation. Chang and coworkers reported one of the first examples with a fluorescence image-based screen to discover an α-cell probe. A group also reported the high-throughput imaging screening of 320 rosamine compounds and discovered two fluorescent molecules with specific localization in the neural bodies and their projections as well as a good colocalization with commercially available neural tracers. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1021/cr200355j | |
dc.source | Scopus | |
dc.type | Review | |
dc.contributor.department | CHEMISTRY | |
dc.description.doi | 10.1021/cr200355j | |
dc.description.sourcetitle | Chemical Reviews | |
dc.description.volume | 112 | |
dc.description.issue | 8 | |
dc.description.page | 4391-4420 | |
dc.description.coden | CHREA | |
dc.identifier.isiut | 000307200000003 | |
Appears in Collections: | Staff Publications |
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