Please use this identifier to cite or link to this item: https://doi.org/10.1021/cr200355j
DC FieldValue
dc.titleCombinatorial strategies in fluorescent probe development
dc.contributor.authorVendrell, M.
dc.contributor.authorZhai, D.
dc.contributor.authorEr, J.C.
dc.contributor.authorChang, Y.-T.
dc.date.accessioned2014-10-16T08:49:12Z
dc.date.available2014-10-16T08:49:12Z
dc.date.issued2012-08-08
dc.identifier.citationVendrell, M., Zhai, D., Er, J.C., Chang, Y.-T. (2012-08-08). Combinatorial strategies in fluorescent probe development. Chemical Reviews 112 (8) : 4391-4420. ScholarBank@NUS Repository. https://doi.org/10.1021/cr200355j
dc.identifier.issn00092665
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/95552
dc.description.abstractStudies relating to the role of combinatorial and high-throughput strategies in the development of fluorescent probes during the last five years, mainly as a result of the expansion of combinatorial chemistry on fluorescent scaffolds and the major improvements in high-throughput screenings and imaging methodologies, are discussed. A group of Lu has engineered libraries of catalytic DNA to prepare sensors for Pb2+ and Zn2+ ions. Chang and co-workers reported a diversity-oriented fluorescent library for the development of photostable near-infrared (NIR) dyes and derivatized a tricarbocyanine structure by nucleophilic substitution with 80 amines and subsequent acetylation. Chang and coworkers reported one of the first examples with a fluorescence image-based screen to discover an α-cell probe. A group also reported the high-throughput imaging screening of 320 rosamine compounds and discovered two fluorescent molecules with specific localization in the neural bodies and their projections as well as a good colocalization with commercially available neural tracers.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1021/cr200355j
dc.sourceScopus
dc.typeReview
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1021/cr200355j
dc.description.sourcetitleChemical Reviews
dc.description.volume112
dc.description.issue8
dc.description.page4391-4420
dc.description.codenCHREA
dc.identifier.isiut000307200000003
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

380
checked on Aug 13, 2019

WEB OF SCIENCETM
Citations

367
checked on Aug 5, 2019

Page view(s)

81
checked on Aug 17, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.