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Title: Combinatorial strategies in fluorescent probe development
Authors: Vendrell, M.
Zhai, D.
Er, J.C.
Chang, Y.-T. 
Issue Date: 8-Aug-2012
Citation: Vendrell, M., Zhai, D., Er, J.C., Chang, Y.-T. (2012-08-08). Combinatorial strategies in fluorescent probe development. Chemical Reviews 112 (8) : 4391-4420. ScholarBank@NUS Repository.
Abstract: Studies relating to the role of combinatorial and high-throughput strategies in the development of fluorescent probes during the last five years, mainly as a result of the expansion of combinatorial chemistry on fluorescent scaffolds and the major improvements in high-throughput screenings and imaging methodologies, are discussed. A group of Lu has engineered libraries of catalytic DNA to prepare sensors for Pb2+ and Zn2+ ions. Chang and co-workers reported a diversity-oriented fluorescent library for the development of photostable near-infrared (NIR) dyes and derivatized a tricarbocyanine structure by nucleophilic substitution with 80 amines and subsequent acetylation. Chang and coworkers reported one of the first examples with a fluorescence image-based screen to discover an α-cell probe. A group also reported the high-throughput imaging screening of 320 rosamine compounds and discovered two fluorescent molecules with specific localization in the neural bodies and their projections as well as a good colocalization with commercially available neural tracers.
Source Title: Chemical Reviews
ISSN: 00092665
DOI: 10.1021/cr200355j
Appears in Collections:Staff Publications

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