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|Title:||Combinatorial strategies in fluorescent probe development||Authors:||Vendrell, M.
|Issue Date:||8-Aug-2012||Citation:||Vendrell, M., Zhai, D., Er, J.C., Chang, Y.-T. (2012-08-08). Combinatorial strategies in fluorescent probe development. Chemical Reviews 112 (8) : 4391-4420. ScholarBank@NUS Repository. https://doi.org/10.1021/cr200355j||Abstract:||Studies relating to the role of combinatorial and high-throughput strategies in the development of fluorescent probes during the last five years, mainly as a result of the expansion of combinatorial chemistry on fluorescent scaffolds and the major improvements in high-throughput screenings and imaging methodologies, are discussed. A group of Lu has engineered libraries of catalytic DNA to prepare sensors for Pb2+ and Zn2+ ions. Chang and co-workers reported a diversity-oriented fluorescent library for the development of photostable near-infrared (NIR) dyes and derivatized a tricarbocyanine structure by nucleophilic substitution with 80 amines and subsequent acetylation. Chang and coworkers reported one of the first examples with a fluorescence image-based screen to discover an α-cell probe. A group also reported the high-throughput imaging screening of 320 rosamine compounds and discovered two fluorescent molecules with specific localization in the neural bodies and their projections as well as a good colocalization with commercially available neural tracers.||Source Title:||Chemical Reviews||URI:||http://scholarbank.nus.edu.sg/handle/10635/95552||ISSN:||00092665||DOI:||10.1021/cr200355j|
|Appears in Collections:||Staff Publications|
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